Sarosh Rana, MD

2011 DICP Faculty Fellowship Alumni

SAROSH RANA, MD, Associate Professor of Obstetrics/Gynecology, University of Chicago Medicine

Mentor: S. Ananth Karumanchi, MD, Associate Professor of Medicine, Harvard Medical School; Beth Israel Deaconess Medical Center—Renal Division

Department Chair: John Yeh, MD,  Professor of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School; Head of the Department of Obstetrics, Gynecology and Reproductive Biology, Beth Israel Deaconess Medical Center

Project Title: "Improving the Diagnostic and Prognostic Assessment of Preeclampsia in Pregnant Women"

Project Description:

Preeclampsia (PE) is the most common medical complication of pregnancy and effects 5-10% of pregnant women. It is the leading cause of maternal death and premature delivery. PE is characterized by new onset hypertension and proteinuria occurring after 20 weeks of gestation. Currently, the only treatment for PE is delivery. Recent research has shown that antiangiogenic proteins are elevated, while levels of proangiogencic proteins are reduced in women with PE. The current standard of care for diagnosis of PE is a time-consuming clinical evaluation that may often be inaccurate. In addition, PE can develop into a life-threatening condition for the mother and her baby without any preceding signs or symptoms. This, coupled with the absence of a definitive test, leads to over diagnosis and consequently iatrogenic prematurity. Currently, there are no available biomarkers to predict PE or its adverse outcomes. Although angiogenic proteins are associated with diagnosis of PE, the clinical utility of these proteins in diagnosing PE or predicting outcomes is unknown. We wish to investigate whether measuring angiogenic biomarkers in pregnant women with symptoms of PE will result in more accurate and quicker diagnosis and whether alterations in these markers correlate with adverse pregnancy outcomes. We will prospectively collect blood from pregnant women at the time they present for PE evaluation and measure angiogenic protein levels and compare these data with the clinical diagnosis and pregnancy outcomes. This work will help determine if these biomarkers have clinical utility that may lead to improved maternal and fetal outcomes.

Biography:

Sarosh Rana, M.D. is an Associate Professor of Obstetrics/Gynecology at the University of Chicago Medicine. Formerly Dr. Rana was a Maternal Fetal Medicine specialist and clinical researcher in the department of Obstetrics and Gynecology at Beth Israel Deaconess Medical Center, and an instructor of Obstetrics, Gynecology and Reproductive Biology at Harvard Medical School. 
Dr. Rana received her medical degree in India. She completed her residency in Obstetrics and Gynecology at the University of Chicago in 2005 and fellowship in Maternal Fetal Medicine at Brown University, Rhode Island in 2008. Dr. Rana works in the laboratory of Dr. Ananth Karumanchi on several translational and clinical projects related to preeclampsia, one of the most common medical complications of pregnancy.  Dr. Rana is specifically involved in clinical studies to evaluate if angiogenic factors correlate with clinical diagnosis of preeclampsia and its associated adverse maternal and fetal outcomes. She aims to evaluate clinical utility of these biomarkers for risk stratification in pregnant women with preeclampsia who present to the obstetrical triage unit. Her research work is partially supported by a Women’s Reproductive Health Research fellowship.